Coronary Artery Disease
 
Treatment:

< Back

Probably the most important way to improve the long-term outcome for patients with coronary disease is prevention. This includes quitting smoking, taking up a healthy diet and regular exercise. Patients with high blood pressure and cholesterol, and diabetes also need to be identified and treated — the use of aspirin and statins (to reduce cholesterol) have been shown to improve the outcome of patients with coronary disease and to reduce the risk of a heart attack
Drug treatments for angina work in two main ways — either by reducing the amount of oxygen needed by the heart muscle (beta-blockers), or by increasing blood flow to the heart (nitrates and calcium channel blockers). Aspirin should be taken by everyone with angina because it works by thinning the blood which then clots less easily; aspirin has been shown to reduce the risk of heart attack by 25 per cent in people with coronary artery disease.
Treatment of a heart attack requires urgent reopening of the blocked artery, to restore the normal blood supply to minimise death of the heart muscle. This can be achieved by clot dissolving drugs (thrombolytic therapy) and/or emergency coronary angioplasty which is increasingly recognised as the gold standard for treatment.

Coronary Angiography (cardiac catheter)


When angina occurs despite drug treatment or when there are features which suggest that the narrowings in the coronary arteries may determine a patients life span coronary angiography is recommended..
Following local anaesthetic a long, flexible, hollow plastic tube (a catheter) is inserted into an artery in the groin. Using X-ray imaging the catheter is steered through the blood vessels and into the coronary arteries at the start of the aorta (main blood vessel from the heart to the body). A special dye (contrast liquid) which is injected into the tube shows up under X-ray to reveal if the coronary arteries are narrowed or blocked. The procedure has some RISKS but seeing the extent and position of the narrowings in the coronary arteries allows a cardiologist to determine the best method of treating angina.


Coronary Angioplasty/stenting Blood flow to the cardiac muscle can be improved by making the blood vessels wider. During angioplasty/stenting (also called PCI - percutaneous coronary intervention) a balloon-tipped catheter is threaded over a guide wire until it reaches the narrowed area (as identified in an angiogram ). When in position, the balloon is inflated at high pressure, compressing the obstructing atheromatous plaque and enlarging the inner diameter of blood vessels so that blood flows more readily. This procedure is known as balloon angioplasty
Angioplasty was introduced in 1979 but "elastic recoil", where arteries return to their original size following removal of the balloon and “restenosis” the development of scar tissue at the site of balloon inflation were responsible for re-narrowing of the vessel in 20 – 50% of patients.

 A right coronary artery with a critical stenosis (narrowing) in its mid portion.  This narrowing is restrictive and limits blood to the areas beyond it causing angina pain.  A wire has been passed and a balloon containing a stent is inflated within the narrowing.  Once the balloon is deflated the stent remains scaffolding the artery wide open and removing the narrowing.  This allows normal blood flow through this portion of the artery and abolishes symptoms.

Click to enlarge Image 1
and to see video
Click to enlarge Image 2
and to see video
Click to enlarge Image 3
and to see video

 "Stents" were incorporated to prevent elastic recoil and to reduce the chances of the coronary artery occluding soon after balloon inflation. The stent (a tiny cage of surgical grade stainless steel) surrounds the outside of the balloon and as the balloon is inflated the stent expands and locks into place to form a scaffold, holding the artery open once the balloon has been removed. All interventional procedures have an element of risk but the chances of a successful outcome in a non emergency situation are >98%.
Inevitably some injury occurs to the artery occurs during stent placement. This can trigger a healing process where scar tissue collects on the inside of the stent, making the stented vessel narrow again. It is most likely to occur in small vessels long stents and in people with diabetes.

 


Stent being deployed

Drug "eluting" stents have now been developed to stop the growth of the scar tissue. They use a small amount of immunosuppressive drug loaded on to the stent to prevent vascular smooth muscle cells dividing and proliferating. These vascular cells are a key component of the scar tissue. Studies performed in Oxford by Dr Banning using these stents have shown excellent results with this technology. In the TAXUS 2 study Drug "eluting" stents were superior to conventional bare metal stents. These benefits are maintained to >2 years following implantation.


Coronary artery bypass graft operations, also referred to as CABG, involve surgery to harvest a piece of artery or vein from another area of the body where it is not needed (such as the long vein in the leg or an artery in the chest wall). One end of the replacement artery or vein is sewn into the aorta (the large artery leaving the heart) and the other end is attached to the blocked coronary artery just below the blocked area, allowing blood to use this new path to flow freely to the cardiac muscle.
Deciding whether to have angioplasty or bypass surgery can be difficult and it needs careful consideration. Using drug eluting stent technology many patients previously unsuitable for stenting can avoid bypass surgery.

< Back                                    Back to top of Page

 
 

Click here to visit Medical Pages for all your Private Practice needs